Conformational equilibrium in supramolecular chemistry: Dibutyltriuret case

• Karina Mroczyńska,
• Małgorzata Kaczorowska,
• Erkki Kolehmainen,
• Ireneusz Grubecki,
• Marek Pietrzak and
• Borys Ośmiałowski

Beilstein J. Org. Chem. 2015, 11, 2105–2116, doi:10.3762/bjoc.11.227

• calculate the properties of the hydrogen bond critical point. The compounds used in this study and their atom numbering. Possible conformations of 1. Driving forces influencing association exemplified on two "extreme" conformations of 1∙∙∙benzoate. Two possible, extreme multiple hydrogen bonded multimeric

• structures of 1 and VT 1H NMR spectra (from +25 to −40 °C, low temperatures at bottom, CDCl3). The proposed structure explaining unusual behavior of the titration curve for 1∙∙∙9 titration and anisotropy influence on methylene chemical shift. Collective titration curves (H1/H7 and H3/H5 chemical shifts

Multivalent display of the antimicrobial peptides BP100 and BP143

• Imma Güell,
• Rafael Ferre,
• Kasper K. Sørensen,
• Esther Badosa,
• Iteng Ng-Choi,
• Emilio Montesinos,
• Eduard Bardají,
• Lidia Feliu,
• Knud J. Jensen and
• Marta Planas

Beilstein J. Org. Chem. 2012, 8, 2106–2117, doi:10.3762/bjoc.8.237

• - to 8-fold more active than the monomeric peptide against the phytopathogenic bacteria. These results suggest that preassembling antimicrobial peptides to multimeric structures is not always associated with a significant improvement of the activity. In contrast, the carbopeptides synthesized were

• active against human red blood cells pointing out that peptide preassembly is critical for the hemolytic activity. Notably, peptide preassembly resulted in an enhanced bactericidal effect. Keywords: antimicrobial activity; carbopeptides; multimeric structures; oxime ligation; phytopathogenic bacteria

• multivalent compounds exhibited low MIC values against plant and human pathogenic bacteria, a significant multimeric effect was not observed. Our results support the notion that preassembly of antimicrobial peptides to multimeric structures prior to contact with the microbial surface does not necessarily lead